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Diabetes Insipidus

What is Diabetes Insipidus? 

Diabetes insipidus (DI), also called water diabetes, is a condition marked by increased thirst and urination. It is not to be confused with the more common type of diabetes, diabetes mellitus (sugar diabetes). Four underlying conditions can lead to diabetes insipidus.

  • Central DI is the most common type and is caused by destruction of part of the pituitary gland that produces vasopressin, which regulates water balance and urine output from the kidneys. In infants and children, this is often an inherited condition. Other causes include tumors, infections and head injury.
  • Nephrogenic DI occurs when the pituitary produces enough vasopressin but the kidneys fail to recognize it because of an inherited or acquired kidney disease.

Maintaining proper water balance by drinking enough fluids is critical for children with DI as they tend to lose a lot of water with frequent urination and this can lead to dehydration, which can be life-threatening. However drinking too much water is also dangerous as it may lead to a rare condition called water intoxication.


  • Increased thirst
  • Frequent urination
  • Increased urine volume
  • Pale or colorless, watery urine
  • Night-time urination (nocturia)
  • Fatigue due to frequent night-time urination and interrupted sleep


 Definitive diagnosis is most often made with:


  • Water-deprivation test: The child must abstain from drinking fluids for a period of time, after which their urine is tested to determine concentration of particles. 
  • Vasopressin test: The body’s reaction to vasopressin after the hormone is injected in the body 
  • Hypertonic saline infusion test: a mixture of water and salt is given IV and then the patient’s blood is tested for particle concentration and vasopressin levels. 

When to Call for Help

If you see any of the above symptoms in your child or teen, call your pediatrician. Increased urination and odorless, pale urine should always be red flags as they may signal water imbalance.

Also children with DI are at increased risk for dehydration if they don’t replenish the loss of water so they need to be observed for signs of dehydration such as dry mouth, sluggishness, muscle weakness, dizziness, few or no tears when crying, rapid heart beat, fever, no sweating, extreme thirst. 


Medications that deliver synthetic vasopressin are the therapy for central DI. For nephrogenic DI, water pills (diuretics) are used. 

At Hopkins Children’s, diabetes insipidus is treated by the division of Endocrinology.

External Links:


National Institutes of Health 

Diabetes Insipidus Foundation